|
KMID : 0603820130190010079
|
|
Journal of Experimental & Biomedical Science
2013 Volume.19 No. 1 p.79 ~ p.82
|
|
|
Neuroprotective Effect of a Novel Herbmedicine, Hepad on SH-SY5Y Cells
|
|
Kim Eun-Hye
Park Byung-Jun
Kim Jung-Seok
Kim Dong-Hee
Choi Hak-Joo
Kim In-Sik
|
|
|
Abstract
|
|
|
|
Parkinson"s disease is a neurodegenerative disease with a wide range of dopaminergic neuron cell death in the substantia nigra. Oxidative stress and neural degeneration are suggested to be involved in the pathogenesis of Parkinson"s disease. In this study, we investigated whether a novel herbmedicine, Hepad protects against 1-methyl-4-phenylpyridnium [MPP(+)]-induced dopaminergic neurotoxicity in SH-SY5Y cells. We found that pretreatment with Hepad significantly increases the proliferation of SH-SY5Y cells (P<0.05) and reversed the loss of cell viability induced by MPP+. Hepad may be a promising neuroprotective agent for the treatment of neurodegenerative disorders such as Parkinson"s disease.
|
|
|
KEYWORD
|
|
|
Parkinson's disease, Hepad, SH-SY5Y cells, Cytotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|